Spawning more than 50 sequels, spinoffs and related titles, the series has sold more than 29 million copies worldwide, making Mega Man one of the most recognisable characters in video game history.
To celebrate Mega Man's 25th anniversary, Capcom has released free PC crossover Street Fighter X Mega Man, which was created and developed by Singaporean programmer Seow Zong Hui and features characters from the fighting franchise as bosses.
Whether it goes down as a classic remains to be seen, but in the meantime, we want to know which Mega Man game you hold most dear.
Is it one of the classic games from the NES-era, one of Mega Man's RPG adventures, or how about one of his 3D jaunts?
If your favourite isn't on the list, let us know by leaving a comment in the space below:
Watch a Street Fighter X Mega Man trailer below: