Rocksteady Studios took home the top prize of 'Best Game' as well as the award for 'Gameplay' for its acclaimed action-adventure title Batman: Arkham Asylum.
Uncharted 2: Among Thieves received four of the nine awards it was nominated for, including 'Action', 'Use Of Audio', 'Original Score' and 'Story'.
Modern Warfare 2 won the public-voted 'GAME Award', while FIFA 10 picked up gongs for 'Best Of Online' and 'Sports'.
Other winners included Left 4 Dead 2 for 'Multiplayer', Empire: Total War for 'Strategy', Flower for 'Artistic Achievement', Wii Sports Resort for 'Family & Social' and Shrunk! in the 'Ones To Watch' category.
The night was topped off with a BAFTA 'Fellowship' being awarded to Nintendo designer Shigeru Miyamoto, who received a standing ovation.
The winners in full:
Best Game: Batman: Arkham Asylum (Rocksteady Studios, Eidos)
Action: Uncharted 2: Among Thieves (Naughty Dog, Sony)
Artistic Achievement: Flower (thatgamecompany, Sony)
Family & Social: Wii Sports Resort (Nintendo)
Gameplay: Batman: Arkham Asylum (Rocksteady, Eidos)
Handheld: LittleBigPlanet (SCE Cambridge, Sony)
Multiplayer: Left 4 Dead 2 (Valve)
Original Score: Uncharted 2: Among Thieves (Naughty Dog, Sony)
Sports: FIFA 10 (EA Canada, Electronic Arts)
Story: Uncharted 2: Among Thieves (Naughty Dog, Sony)
Strategy: Empire: Total War (The Creative Assembly, Sega)
Use of Audio: Uncharted 2: Among Thieves (Naughty Dog, Sony)
Use of Online: FIFA 10 (EA Canada, Electronic Arts)
BAFTA Ones To Watch Award: Shrunk! (The Butterflyers)
GAME Award of 2009: Call of Duty: Modern Warfare 2 (Infinity Ward, Activision)
BAFTA Fellowship: Shigeru Miyamoto
> Live Blog: BAFTA Video Game Awards 2010
