The Deus Ex creator said that the film critic, who recently declared that the medium can never be considered art, does not understand games and will eventually be replaced by those who do.
"Video games are just coming out of the period where I describe them as the medium adults don't get," Spector told Eurogamer.
"Roger Ebert is like the adult. He doesn't get it. The fact is if we haven't already reached the point where this is true, we're very close to reaching the point where everyone plays games, in the same way that everyone goes to the movies and everyone watches television. We're really at that sort of point where everybody plays games.
"Eventually some other thing will come along that I don't get or you don't get and we'll all say, 'Oh, those kids today, that stuff isn't art'. The same thing happened with movies. Go back to the early days of movies. Go back to the early days of the novel, for crying out loud. That can't be art. Go back to the days when people gave Shakespeare a hard time."
He continued: "Whatever medium adults don't understand can't be art. Eventually those adults go away and new adults take their place, and some other medium takes the place of the thing that everybody hates. We're coming out of that period now. What Roger Ebert thinks is completely irrelevant."
Spector is currently working on Epic Mickey for Nintendo Wii.