It holds off strong competition from Mass Effect 2, jumping six places to second, as well as Sniper: Ghost Warrior in third.
Elsewhere, both Prince Of Persia: The Forgotten Sands and Need For Speed: Drift return to the top ten after spells away from the chart.
The top ten in full:
1. (-) Kane & Lynch 2: Dog Days (Square Enix)
2. (8) Mass Effect 2 (Electronic Arts)
3. (1) Sniper: Ghost Warrior (City Interactive)
4. (2) Red Dead Redemption (Rockstar)
5. (14) Prince Of Persia: The Forgotten Sands (Ubisoft)
6. (19) Need For Speed: Shift (Electronic Arts)
7. (5) Forza Motorsport 3 (Microsoft)
8. (7) Battlefield: Bad Company 2 (Electronic Arts)
9. (3) Madden NFL 11 (Electronic Arts)
10. (6) Splinter Cell: Conviction (Ubisoft)
Leisure software charts compiled by Chart Track, (C) 2008 ELSPA Ltd.