Published by Sega, Thor: God Of Thunder will feature Hemsworth as the title character and Hiddleston as antagonist Loki. Both actors have also lent their likenesses to the game.
"Bringing in Chris and Tom to star in Thor: God Of Thunder gives us AAA talent that will create a truly cinematic interactive experience," said Sega marketing chief Gary Knight.
"Mighty Thor and the trickster Loki will face off with real emotion while giving fans visual and vocal continuity between the video game and film adaptations of the Marvel franchise."
The third-person action adventure pits players against Thor villains from the pages of the Marvel comic and features numerous worlds from Norse mythology. Eisner Award-winning writer Matt Fraction served as story consultant on the title.
Thor: God Of Thunder will be released on "all major video game platforms" in spring 2011. The movie arrives in theatres on May 6.