The first-person shooter will stick to the formula of previous entries in the series, with a cover-free battle system, expansive outdoor environments and hordes of on-screen enemies.
The prequel will see players participate in humanity's last stand as Mental's savage beasts ravage the world's cities and temples.
As well as a campaign supporting up to 16 players co-operatively, it will offer competitive multiplayer modes such as Deathmatch and Beast Hunt.
"Serious Sam 3 is about pure fun and unfiltered action," said chief creative officer Davor Hunski.
"We wanted to expand on everything gamers love about the series while adding some genuinely unique new features to really enhance the mayhem Serious Sam is known for."
Serious Sam 3: BFE will be available on PC and consoles this summer.
The first screenshot for the game was revealed earlier today.