Valve has developed console versions of its games in the past, most recently with Portal 2, but has never had a game appear on a Nintendo system.
"Wii U seems to be a lot more powerful than the previous generation," Newell told Joystiq after his keynote speech. "It sort of fits better into the scalability in terms of graphics performance and CPU performance, so I think it'll be a lot easier for us to fit it into our scalability model."
Newell added: "Now it's a lot easier to look at Wii U and have it fit within that framework."
With Portal 2, Valve launched Steam support on the PlayStation 3. Nintendo's Satoru Iwata previously stated that Wii U's online system will be flexible to the needs of developers. Though Newell did not mention Steam along with the Wii U, a more flexible online system for the Wii U could open up that possibility.
Valve is currently developing an as-yet unnamed free-to-play title for Steam.