Uncharted 3: Drake's Deception lead designer Richard Lemarchand will showcase the title at the Nottingham event, as well as providing a behind-the-scenes look at the first two entries in the PlayStation 3 adventure series.
Journey is to be presented by thatgamejourney's Robin Hunichke, with a late-night showcase of the forthcoming PSN downloadable title.
Another World creator Eric Chachi will curate the first day's proceedings with his latest title From Dust, which launches on Xbox Live and PC later this month.
Finally, Amanita Design's Jakub Dvorsky is to return to GameCity to present new titles Samorost 3 and Botanicula.
"We're hugely excited about this opening lineup for GameCity, it's shaping up to the best yet," said director Iain Simons.
"We're just getting started with the programme for this year, with some huge new headline features yet to be announced."
Last year's GameCity saw Crytek showcase Crysis 2 multiplayer and Jonathan Blow provide a developer's commentary on Braid.
GameCity6 will take place in Nottingham from October 25 to 29.