The title is a side-scrolling exploration game where players will recruit and control 19 different marines to eliminate the xenomorph infestation from iconic environments such as the Derelict Ship and the planet LV-426.
The game is being developed by WayForward, the studio that previously released critically-acclaimed DSiWare titles Mighty Flip Champs, Mighty Milky Way and Shantae: Risky's Revenge.
Aliens: Infestation is developed in collaboration with Gearbox Studios, who will release Aliens: Colonial Marines for consoles in 2012.
Aliens: Infestation will release on Nintendo DS in Europe from September 30 followed by a North American release on October 11.
> Read Digital Spy's preview of Aliens: Colonial Marines
Watch the announcement trailer for Aliens: Infestation below: