IO Interactive's Hakan Abrak told Digital Spy that protagonist Agent 47 will work alone in the Square Enix-published title, and the player will learn more about his character.
"I think one big difference is the story. You've been used to these traditional hits, Diana giving you a hit as the pacing of the story," he said. "It's very different in this one because Hitman has to work alone. He's been betrayed and he's being hunted.
"It's a far more personal story. This time around, Agent 47 makes the next moves and pushes the story. You come a lot closer to Hitman and learn more about him than ever before."
Abrak also outlined some of Absolution's new gameplay features. The game will include significantly improved AI, evolved versions of previous mechanics and the new 'Instinct' mode.
"The other big difference is the technology. We've added new features and really upped the AI - because that's a core part of Hitman - to give those different, funny and weird stories within the story. That we have focused very intensely on," he added.
"We have used very evolved editions of existing mechanics, such as disguise and impersonation, and, as I said before, the AI. Also, there's 'Instinct' mode. The players use 'Instinct' to react to situations. For example, if you are disguised as a doctor you'll write in your notepad to remain undetected, if you are police you'll talk into your radio."
Hitman: Absolution will also feature original game design concepts, distinctive art direction and use of IO Interactive's new Glacier 2 engine. It will be released for Xbox 360, PlayStation 3 and PC in 2012.
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Watch the teaser trailer for Hitman: Absolution below: