The clip sees footage from the two games, both of which are set in the Los Angeles-inspired city of Los Santos, run side-by-side.
The fan-made video highlights the visual change in graphical quality and environmental detail between games.
Grand Theft Auto V's first trailer debuted last week, showing that it will feature planes, mountainous environments and poverty as an ongoing theme.
Rockstar Games has since confirmed that it will be the "most ambitious game" it has ever created.
Analysts have predicted a summer 2012 release date, suggesting that a pre-E3 expo launch in June is likely.
Watch the Grand Theft Auto V and GTA: San Andreas comparison video below: