The premium package has been listed on US retailer GameStop's website, priced at $79.99 (£50).
As well as a copy of the game, it features a metal case, 70-page art book, limited edition Dark Horse Comic, fabric N7 patch, digital soundtrack and an exclusive 4x6 lithographic print of the SR-2 Alliance Normandy.
In-game content includes an N7 Arsenal Pack, the Squad Alternate appearance pack for Ashley Williams, Liara, James Vega and Kaidan, a new mission, bonus character, and a robotic dog for the Normandy.
Mass Effect 3's Galaxy at War mode was announced earlier this year featuring co-operative missions for up to four players.
BioWare recently revealed that the mode will be affected by choices from earlier Mass Effect games.
Mass Effect 3 will be available on Xbox 360, PlayStation 3 and PC from March 6 in the US and March 9 in Europe.
> Read our hands-on multiplayer preview of Mass Effect 3
> Mass Effect 3 campaign to feature action, story, RPG modes
The Collector's Edition packaging in full:
- Premium metal case featuring male and female Commander Shepard
- 70-page hardbound art book
- Limited edition Mass Effect comic by Dark Horse Comics
- Fabric N7 patch.
- Exclusive 4x6 lithographic print of the SR-2 Alliance Normandy
- Additional in-game content including
- N7 Arsenal Pack - Bring the firepower with the N7 Sniper Rifle, Shotgun, SMG, and Pistol.
- Squad alternate appearance pack
- Robotic Dog for on board the Normandy
- Mass Effect 3 digital soundtrack