Taking place ten years after the Raccoon City incident, Resident Evil 6 stars Leon Kennedy and Chris Redfield as they fight a new bioterrorism threat, and sees a return to the series' hallmark zombies.
The trailer shows Leon investigating a zombie-infested small town while Chris arrives in China to confront a new bio-weapon monster.
A mysterious new character is also introduced, whose blood seems to carry the key to unlocking the mystery behind it all.
Earlier today retailers leaked the Resident Evil HD Revival Selection, which will include Resident Evil 5 Gold Edition and the HD versions of Resident Evil 4 and Resident Evil: Code Veronica.
Resident Evil 6 will be available on Xbox 360 and PlayStation 3 on November 20, 2012. A PC release will follow, but has not yet been dated.