Calling Resident Evil 6 "by far the largest production Capcom has ever worked on", executive producer Hiroyuki Kobayashi explained that more than 600 people from across the world helped to produce the game, including 150 staff members in Japan.
Kobayashi also called Resident Evil 6 the most ambitious game in the series, which would "draw from the fundamentals that made the previous Resident Evils so great, but also add entirely new breathtaking aspects and many surprises".
Describing the story as "intricately designed", director Eiichiro Sasaki told the Capcom Unity blog that Resident Evil 6 will feature a mixture of "intense drama, realism and surprising plot twists".
The upcoming sequel takes place ten years after the Raccoon City incident and stars Leon Kennedy, Chris Redfield and a mysterious new character whose blood holds the key to humankind's survival.
Confirmed locations for the new game include the infected town of Tall Oaks, as well as China - the source of the latest bioterrorism attack. Zombies return as the game's primary enemy, as well as a powerful new creature called Javo.
Resident Evil 6 will be available on Xbox 360 and PlayStation 3 on November 20, 2012. A PC release will follow, but has not yet been dated.
Watch the Resident Evil 6 announcement trailer below: