It is followed by Call of Duty: Modern Warfare 3 in second and last week's number one Final Fantasy XIII-2 in third.
Uncharted 3: Drake's Deception makes a return to the top ten at six, above former high flyer Metal Gear Solid HD Collection at seven and The Darkness II at eight.
The top ten in full:
1. (-) UFC Undisputed 3 (THQ)
2. (6) Call of Duty: Modern Warfare 3 (Activision)
3. (1) Final Fantasy XIII-2 (Square Enix)
4. (5) Battlefield 3 (Electronic Arts)
5. (7) FIFA 12 (Electronic Arts)
6. (12) Uncharted 3: Drake's Deception (Sony)
7. (2) Metal Gear Solid HD Collection (Konami)
8. (4) The Darkness II (2K Games)
9. (8) Assassin's Creed: Revelations (Ubisoft)
10. (9) Elder Scrolls V: Skyrim (Bethesda Softworks)
Leisure software charts compiled by Chart Track, (C) 2012 UKIE Ltd.
Watch a trailer for UFC Undisputed 3 below: