Both titles were scheduled to release later this week on Friday, March 9.
"Unfortunately Capcom must confirm that Street Fighter X Tekken for PlayStation 3 and Xbox 360 and Asura's Wrath, both scheduled for release on Friday, March 9, will not be stocked by GAME or Gamestation either in their retail outlets or on their online stores operating in the UK and Ireland," Capcom said.
"Capcom wants to reassure its consumers that both these titles, including the Special Edition of Street Fighter X Tekken, will be available at a wide variety of retailers across the UK and Ireland.
For those consumers who have already placed a deposit for a pre-order for any of these titles then a full refund will be available - please contact your local GAME or Gamestation shop or visit the online stores."
It is the latest in a series of problems for the retailer, which includes the GAME and Gamestation stores. The firm's inability to stock Electronic Arts releases such as Mass Effect 3 means that it stands to lose out on £2.5m in profit.
Capcom stated that no decision has been made yet about whether GAME stores will carry Resident Evil: Operation Raccoon City, which releases March 23.
GAME recently announced 35 store closures and shut down sister website gameplay.co.uk.
The high street retailer's shares plummeted by 90% in 2011, despite £1 billion in annual turnover.
> Everything must go: Is this the death of games retail?