The spin-off is a departure for the best-selling iOS series, with a top-down viewpoint, hack-and-slash gameplay and a crafting system not unlike Diablo.
Set thousands of years before the first two Infinity Blade games, players will assume the role as an apprentice weaponsmith serving the Master of the Forge, who sets out to create the Infinity Blade.
It uses the new iPad's A5X chip and Retina Display screen for improved visuals, including high dynamic range (HDR) imaging and better lighting.
"Apple has raised the bar today for mobile computing," said president of Epic Games Mike Capps at the announcement.
He added that the new iPad has more memory and higher resolution than home consoles Xbox 360 and PlayStation 3.
Epic Games announced Infinity Blade II alongside the iPhone 4S last October.
> Read our review of Infinity Blade II