Furthermore, Warriors Orochi 3 will not be sold by the UK games retailer.
"Capcom must confirm that the Xbox 360 and PlayStation 3 versions of Resident Evil: Operation Raccoon City... will not be stocked by GAME or Gamestation or on their online stores operating in the UK and Ireland," read a statement issued to Digital Spy.
They previously announced that Street Fighter x Tekken and Asura's Wrath would not be sold by GAME.
Elsewhere, Tecmo Koei Europe said: "[We regret] to announce that upcoming releases Ninja Gaiden 3 and Warriors Orochi 3 for the [Xbox 360 and PlayStation 3] will not be available through GAME and Gamestation retail outlets or online in the UK and Ireland."
It was reported earlier today that GAME could be bought by Comet owner OpCapita after the retailer had put itself up for sale.
The chain recently announced 35 store closures and that it is going to shut sister website gameplay.co.uk.
In addition, GAME's shares plummeted by 90% in 2011, despite £1 billion in annual turnover.
> Everything Must Go: Is this the death of games retail?
Read Capcom's statement in full:
"Further to the recent announcement concerning Street Fighter x Tekken and Asura's Wrath, Capcom must confirm that the Xbox 360 and PlayStation 3 versions of Resident Evil: Operation Raccoon City scheduled for release on Friday March 23, will not be stocked by GAME or Gamestation either in their retail outlets or on their online stores operating in the UK and Ireland.
"Capcom wants to reassure its consumers that this title will be available at a wide variety of retailers across the UK and Ireland. For those consumers who have already placed a deposit to pre-order of Resident Evil Operation Raccoon City then a full refund will be available - please contact your local GAME or Gamestation shop or visit the online stores.
"Resident Evil: Operation Raccoon City is available for pre-order or to purchase on day of release from the following outlets: Blockbusters, HMV, Play.com, Amazon.co.uk, Shopto.net, The Hut and leading independent stockists as well as supermarket chains."
Watch a trailer for Resident Evil: Operation Raccoon City below: