Unlike similar games such as Guitar Hero and Rock Band, Rocksmith uses a real electric guitar to teach players the notes and chords to play its assortment of songs.
For users who do not already own an electric guitar, Rocksmith will offer a bundle that includes a Gibson Epiphone Les Paul Junior guitar as well as the real tone cable, allowing the guitar to connect with an Xbox 360, PlayStation 3, PC or Mac. The bundle is currently listed on Amazon for £122.
The UK release will feature an expanded tracklist, including the 45 tracks from the North American release plus additional content for over 50 total songs from artists including David Bowie, The Rolling Stones, Nirvana and Muse.
"Rocksmith has already seduced hundreds of thousands in North America and we are very proud to bring this game into our territories," Ubisoft chief marketing and sales officer Geoffroy Sardin said.
"The main reason for this success is that Rocksmith offers so much more than previous guitar games: the possibility to actually master a real instrument."
Rocksmith will be available on September 14 for Xbox 360, PlayStation 3, PC and Mac.