The Wii U's tablet controller will serve as a link between the in-game action and the Animus, reports Nintendo Power (via Eurogamer).
In addition to storing character information and biographies, the tablet controller enables players to change weapons without pausing the action.
Players can also use the controller's built-in accelerometer to control the camera during Eagle Vision mode, as well as a map and navigation tool.
Assassin's Creed III was recently revealed by Ubisoft. It will take place over a 30-year period in colonial America beginning in 1777.
It features a brand new lead named Connor, the offspring of an English father and Native American mother.
New abilities are expected to feature in the game, such as climbing trees and hunting wildlife. Ubisoft president Yves Guillemot has called Assassin's Creed 3 the "biggest in the series to date".
Assassin's Creed 3 will be released for Xbox 360, PC, PlayStation 3 and Wii U on October 31 worldwide.
> Read our review of Assassin's Creed Revelations
View a trailer from Assassin's Creed 3 below: