Alex Hutchinson, the game's creative director, revealed to GameSpy that less attention will be paid to mouse and keyboard controls.
"We're definitely supporting PC, we love PC, but I think it'll be PC with a controller," he said.
"I don't see us investing hugely in a mouse and keyboard setup. I think if you want to play on PC and you want to play Assassin's Creed, you have a controller."
Ubisoft has a history of favoring console development over the PC version of its games, with the PC versions often receiving last-minute delays and always-on DRM.
The game will arrive on Xbox 360, PlayStation 3 and PC in three collector's editions.
A Wii U version is also in development, which will use the tablet controller in a number of unique ways.
Assassin's Creed 3 will be released on October 31 worldwide.
> Digital Spy's first-look preview of Assassin's Creed 3
View the latest screenshots of Assassin's Creed 3 below: