The retail giant is positioning itself as "The Home of Gaming" following GAME's recent entry into administration.
Set against an image of a PS3 controller, the advertising campaign claims that Tesco has the largest number of gaming stores within the UK, and a catalogue of 10,000 video games online.
The ad also highlights Tesco's Clubcard offer, its pre-order price promise and its nationwide pre-owned games scheme.
Tesco is the latest retailer to try to reel in GAME customers, following ShopTo's controversial GAME reward points offer, and Blockbuster's recently announced Kinect Star Wars midnight launch.
The GAME Group has so far shut the doors of 277 of its 609 shops in the UK and Ireland, laying off around 40% of its workforce - roughly 2,104 employees.
GAME CEO Ian Shepherd resigned from his role with immediate effect after administrators PwC (PricewaterhouseCoopers) were appointed to handle any potential sale.
GAME Group announced its intentions to file for administration following the firm's delisting from the London Stock Exchange.
An RBS-led bank consortium is "incredibly close" to saving the retailer from administration, reports have suggested.
The high street retailer's shares plummeted by 90% in 2011, despite £1 billion in annual turnover.
> Everything must go: Is this the death of games retail?
Photo gallery - view pictures from the Modern Warfare 3 launch at GAME below: