The Star Trek: The Next Generation and Breaking Bad actor will take on the starring role of Professor Fitz Quadwrangle.
"The professor's character is funny, a bit bizarre, and a great joy to perform," de Lancie said. "If players have half as much fun with the game as I did playing the character, then they'll be having a great time."
The game will see players make their way through the puzzle-filled mansion guided by Professor Quadwrangle, who is trapped in another dimension.
To solve puzzles, a special glove can be used to shift the world through different dimensions that change the environment, such as the 'slow motion' dimension or 'fluffy' dimension.
Quantum Conundrum will be available on Xbox Live Arcade, PlayStation Network and PC this summer.
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Watch the trailer for Quantum Conundrum below: