The latest video features in-game action, including a gun fight in the Philippines and an intense shooting section on board of a boat.
The video also unveils some of the factions available during multiplayer, including British SAS, US SEAL's and Russian SPETSNAZ.
The shooter follows US Tier 1 Operator 'Preacher' returning to his family back home. However, the peace is shattered by explosive detonations in civilian territory, calling him and his squad back into action.
Going beyond the location of Afghanistan from the original game, it sees Tier 1 travel the globe in missions that mirror real-world events, such as eliminating pirates on the Somali Coast.
Campaign missions will feature a degree of choice, elements of co-op and returning characters. A one-shoot-kill hardcore mode will also be included.
Those who pre-order the game will unlock the Tier 1 Sniper on the day of launch, a weapon said to take 40 hours to otherwise unlock.
Medal of Honor: Warfighter will be once again developed by Danger Close using Battlefield 3's Frostbite 2 engine.
It releases for Xbox 360, PS3 and PC on October 23 in North America and October 26 in Europe.
> Read our review of Medal of Honor
Picture gallery - view images from Medal of Honor: Warfighter below: