Customers who have pre-ordered the game will be able to participate in the event from April 27-29.
In addition to event entry, pre-ordering Guild Wars 2 grants access to the Hero's Band in-game item, as well as three-day Headstart Access prior to launch.
Guild Wars 2 weekend events are expected to take place on a monthly basis until the game releases later this year.
The long-awaited sequel to Guild Wars was announced in 2007. The game has been hit with numerous delays in the five years since it was unveiled.
Set in Tyria, which is one the verge of an industrial revolution, it takes place 250 years after the defeat of the Great Destroyer in the original game's Eye of the North expansion.
There are five races available to each player, as well as multiplayer battles involving up to 400 participants.
Guild Wars 2 is due to be released for the PC later this year.
> 'Guild Wars 2' preview: Hands-on with ArenaNet's impressive MMO sequel
Watch a trailer for Guild Wars 2 below: