The debut gameplay video showcases the game's impressive visuals and action set-pieces.
Largely taking place in urban rainforest locations, the gameplay trailer highlights the power of the CryEngine 3, which is capable of producing stunning lighting and environmental effects.
The video also features a first look at some of the game's enemies, weaponry and Nanosuit powers, including the stealth ability, which is used to sneak up on and destroy unsuspecting foes.
Announced last week, Crysis 3 sees Prophet discovering that New York has been encased in a 'Nanodome' by the Cell Corporation.
The dome has created a natural environment within the city, adding a rainforest, swamplands and rivers, as well as seven distinct locations named the Seven Wonders.
The game's creative director Rasmus Hoejengaard told Digital Spy that the return to New York was not an attempt to "cut corners or reuse assets", but to create a stronger emotional impact for both returning players and Americans.
Crysis 3 will be released on PlayStation 3, Xbox 360 and PC in spring 2013.
> Read our first-look preview of Crysis 3
Photo gallery - view screenshots of Crysis 3 below: