The outdoor advert, shown post-watershed due to explicit content, had actors recreating various moments from the game that culminated in a battle between the first game's Alex Mercer and sequel protagonist James Heller.
The audience got the chance to vote on how the live advert's climactic battle would end, choosing Mercer as the victor.
Prototype 2, the sequel to Radical Entertainment's 2009 action game, features new protagonist James Heller embarking on a violent revenge mission aided by mutated super powers. The game's tagline is "Murder your Maker".
Prototype 2 is available now on Xbox 360 and PlayStation 3. The PC version will follow on July 24.
Photo gallery - Prototype 2 live advert: