The 2D fighter will be available to download from Steam, Origin, GameFly, GameStop PC Downloads and GamersGate this autumn
"We hope to have PS3/PC cross-platform play implemented a few months after the PC version is released," read a post on the game's official Twitter feed.
Skullgirls will not use Games for Windows Live, but it is yet to be confirmed whether it will support Steamworks or another platform.
The Reverge Labs title, published by Def Jam Rapstar studio Autumn Games, was released via Xbox Live and the PlayStation Network last month.
Skullgirls for PC is yet to be assigned a specific release date.
> 'Skullgirls' story trailer released - watch
Watch the Skullgirls launch trailer below: