The video provides an overview of the game from its story to customisation and multiplayer.
The launch trailer also showcases each of the five classes players can choose through gameplay footage. Players can pick to be a Barbarian, Witch Doctor, Demon Hunter, Monk or Wizard as they adventure through randomly generated dungeons with up to three friends.
To mark the release of the long-awaited sequel, Blizzard has announced that it will hold a series of global events to celebrate its launch.
A Collector's Edition of the game will be available at retail, which includes the game's soundtrack, a two-disc behind-the-scenes DVD and Blu-ray set, an art book and a 4GB USB soulstone flash drive loaded with the full games of Diablo II and its expansion Lord of Destruction.
Blizzard is also offering Diablo III free to users who sign up for the World of Warcraft annual pass, a yearly subscription to the popular MMO.
Diablo 3 will unlock tonight at 11pm for all users, when you can read Digital Spy's live first-hand impressions of the game's first few hours.
Watch the opening cinematic for Diablo 3 below: