Nintendo will show a new Wii U game titled Acid Ghost, a title aimed at an older audience, according to Go Nintendo.
© Rex Features / Jon Beretta
© Nintendo
Eminem will appear in a video that shows him playing the game, which is currently in post-production at a marketing agency in Sacramento in California.
The rap artist previously appeared in 50 Cent: Bulletproof in 2005, providing the voice of a crooked cop.
Earlier this year, Eminem was sued by a homeless man for $9 million.
The Wii U's launch lineup was reported to have leaked earlier this month.
Nintendo has since confirmed it will show Pikmin 3 and a new Super Mario Bros. game at its press conference.
E3 2012 will take place between June 4-7.
> Nintendo not announcing Wii U date or price at E3
See Eminem's appearance in 50 Cent: Bulletproof below:
