The video features pre-rendered footage of Death fighting an enormous golem-like enemy reminiscent of Shadow of the Colossus.
The trailer also highlights Death's ability to transform, changing to a more traditional grim reaper attire and carrying a massive scythe.
The story of Darksiders 2 will run parallel to that of the first Darksiders game. Players will take on the role of the horseman Death as he travels through the Abyss to redeem his brother War and undo the apocalypse.
THQ previously announced a number of pre-order bonuses for Darksiders 2 available at various retailers as well as a Collector's Edition.
Darksiders 2 was recently delayed until August so that the development team could add more polish. It will now arrive on Xbox 360 and PlayStation 3 on August 26.
Watch Part 1 of the Darksiders 2 Death Strikes trailer below: