The latest video sees the lead character and female accomplice Lisa attempt to escape a burning building.
The exciting set-piece begins as a rescue mission, before players push start a Jeep in order to escape.
The trailer releases on the same day that Ubisoft registered a Face Your Insanity web domain, which is likely to be related to Far Cry 3, reports VG247.
Last month, Ubisoft released details about two of the game's multiplayer modes.
Firestorm and Domination were confirmed alongside the return of the map editor.
Firestorm sees players rush to an opposing team's fuel supplies, and set it and most of the map on fire. From there, the teams then fight over a radar to call in planes that will torch the rest of the map, or douse it with water.
Meanwhile, Domination is a more traditional mode of capturing and holding points across the map.
Far Cry 3 will be available on Xbox 360, PS3 and PC September 4 in North America and September 7 in Europe.
> Far Cry 3 multiplayer preview
Screenshot gallery - View images from Far Cry 3 below: