The video introduces Earthgov Sergeant John Carver, who must defend a residential colony from a necromorph invasion after an attack on the nearby Marker Site.
The trailer shares many similarities to speculation surrounding EA's Dead Space 3.
Early rumours suggested that the next Dead Space title would take place on the frozen planet Tau Volantis, which is strikingly similar to the teaser trailer's frozen planet Uxor.
The new protagonist, John Carver, also features a large facial scar, consistent with rumours that Dead Space 3 will feature a co-operative character with a "gnarly scar on his face".
The trailer appeared on the official Dead Space website stating that it is "the start of John Carver's saga in the Dead Space Universe".
The site also features a countdown timer written in cryptic symbols. Digging into the page's code reveals that the timer is counting down to EA's pre-E3 press conference on June 4.
Dead Space 3, the sequel to Visceral Games' survival horror third-person shooter Dead Space 2, will launch within the next financial year, EA confirmed earlier this month.
Watch a trailer for Dead Space 2 below: