Footage from the game was used to close Sony's E3 press conference last night. It combines stealth gameplay with third-person shooter action.
Announced at last year's Spike TV VGAs, The Last of Us follows two survivors in a world turned upside down by a fungus-like virus.
The adventure will be set in a more colourful world than other post-apocalyptic games, using overgrown vegetation in cities to add variety.
Both gunplay and melee combat will be an important part in the game, with weapons breaking after continued use, requiring the player to find new items regularly.
Work on the project began after Uncharted 2: Among Thieves and it has been in development for over two years.
The Last of Us will be released exclusively on PlayStation 3 in 2013.
> Digital Spy's E3 Gaming Expo 2012 complete coverage
View the first screenshots of The Last of Us below: