The game goes offline at 2am (BST) and is estimated to return at 12pm (BST) the same day.
The service disruption is due to the implementation of patch 1.03, which tweaks the Inferno difficulty level and adds bonus damage to enemies when playing as a group.
Players will not be prompted to download the patch until it is live in their region.
"If you are logging in from a European or Asian client, you will need to wait for this patch to release in that region before it can be installed," explains Blizzard on battle.net.
"Additionally, if your home region is the Americas, you will be unable to log into Europe or Asia using Global Play after patch 1.0.3 is live until those regions have also patched."
Blizzard recently introduced real-money auction houses to Diablo 3, as well as an update that will optimise the game for use on the new MacBook Pro line with Retina displays.
Diablo 3 launched last month. The game is free to users who sign up for the World of Warcraft annual pass, a yearly subscription to the popular MMO.
A Starter Edition of the game has also been confirmed, offering a limited introduction to Diablo 3 with content similar to its private beta.
> Read Digital Spy's Diablo 3 review
Watch the Diablo 3 launch trailer below: