Specifically, Sega offices in France, Germany, Spain, Australia and Benelux will see closures.
Koch Media, the parent company of Dead Island developer Deep Silver, will now take over distribution responsibilities for Sega's titles in Germany, Switzerland, Austria, France and Spain.
Meanwhile Level03 Distribution and 5 Star Games will deliver Sega's games for Australia and Benelux.
"SEGA is entering a new and exciting phase that will position the company as a content led organisation maximising sales with strong and balanced IP such as Sonic the Hedgehog, Total War, Football Manager and the Aliens franchise," Sega Europe COO Jurgen Post said of the closures.
"The company will benefit from a clear focus and realigned strategy for our digital business and packaged goods and we are confident that this will lead to a successful future."
Sega's European headquarters in London will remain open and continue to manage the company's European operations, including overseeing distribution partners Koch Media, Level03 Distribution and 5 Star Games.
The office closings are part of Sega's ongoing restructuring efforts after suffering an "extraordinary loss" in its last fiscal year.
One title that seems to be caught in limbo due to the publisher's office shuffling is Anarchy Reigns, which was recently delayed to an unspecified date in 2013 despite the game being finished and already localised for a Western release.
Watch the Anarchy Reigns Japanese launch trailer below: