The Japanese gameplay video reveals a spring 2013 release date for the Nintendo 3DS-exclusive.
It also showcases the game's impressive visuals, featuring the series' trademark screen-filling beasts and stunning environments.
The game is the follow-up to Monster Hunter Tri G, which was one of the first titles to confirm the use of the 3DS Circle Pad Pro.
The second circle pad was a surprise omission from the recently announced Nintendo 3DS XL.
Releasing in Europe on July 28 and North America in August, the 3DS XL features bigger screens and an improved battery life.
Picture gallery - view images of the 3DS XL below: