The concept was backed by more than 10,000 people on the LEGO website, which means that the idea will be the subject of an official review.
The LEGO team will now build a series of Portal concept kits, which will go before a panel in September.
A LEGO set based on The Legend of Zelda is also under official consideration.
Harry Potter, Indiana Jones, Pirates of the Caribbean and Star Wars are among the properties to have received the LEGO treatment for video games.
LEGO Batman 2: DC Super Heroes is the most recent LEGO release, launching across multiple platforms last month.
LEGO Lord of the Rings is also in the pipeline, releasing for the Xbox 360, PS3, Nintendo Wii, DS, 3DS, PlayStation Vita and PC this autumn.
> Read our LEGO Batman 2: DC Super Heroes review
> Feature: LEGO video game retrospective
Watch a trailer for LEGO Lord of the Rings below: