Announced earlier this year, the new single rating system replaces the previous model featuring both BBFC and PEGI classifications.
The rating system will be enforceable by UK law, where selling a game to someone underage can result in a £5,000 fine and a jail sentence of up to six months.
The Video Standards Council, under the operating name of the Games Ratings Authority (GRA), will rate the games under PEGI's guidance, as well as ensuring that retailers comply with the new system.
With one in three parents admitting to buying an unsuitable video game for their children, and 86% believing a single classification body is a good thing, UKIE has relaunched the Ask About Games website to help educate parents.
It has also developed the Control.Collaborate.Create. campaign, which includes a video hosted by TV and radio presenter Jo Whiley.
Believing a single rating scheme will make it easier for parents to choose the right game, Whiley said: "My family and I love playing video games together, but as a parent I know it can sometimes be hard to know the best games to choose.
"That's why I'm pleased to be supporting the Control.Collaborate.Create. campaign.
"This campaign, and the implementation of PEGI as the single age rating system for video games in the UK, will make it easier than ever for parents to make the best video games choices for their whole family."
Kim Bayley of the Entertainment Retailers Association also expressed her delight at the introduction of a singular scheme, believing it will provide greater clarity for retailers.
"Retailers have worked hard with their suppliers to ensure a successful introduction of the new system, which we believe will provide greater clarity for consumers and in particular reassurance to parents that the games their children play are appropriate to their age," Bayley remarked.
GAME's Anna-Marie Mason echoed the statements, saying: "GAME and gamestation apply rigorous training and audit standards to make sure that PEGI is understood by colleagues and customers alike.
"The framework is very clear and ensures that we guide customers correctly and responsibly. We're hugely supportive of PEGI in this new era."
The changes come more than three years after a government report favoured PEGI ahead of the BBFC in the battle to provide a simpler rating system.
PEGI was also backed by a member of the European Parliament when the debate began in 2009.