'Agent Hunt' allows multiple players to infiltrate a user's single-player campaign as one of the game's various creatures, reports Andriasang.
The mode will be available after completing the main campaign. Users will be able to replay levels under 'Agent Hunt' rules, not knowing which enemies are human-controlled.
Monsters, meanwhile, will be able to use voice commands to co-ordinate attacks in order to successfully eliminate an agent.
Announced earlier this year, Resident Evil 6 will be available on Xbox 360 and PlayStation 3. A PC release will follow, but has not yet been dated.
The upcoming sequel is set 15 years after the Raccoon City incident and takes place in the infected town of Tall Oaks, as well as China.
The game is Capcom's largest ever production, with more than 600 staff involved in its development.
A demo launched last week for Xbox 360 Dragon's Dogma owners.
The demo, which features three different missions, will remain an Xbox 360 exclusive until September, when it releases for the PS3.
Resident Evil 6 will be available on Xbox 360 and PlayStation 3 on October 2. A PC release will follow, but has not yet been dated.
> Resident Evil 6 preview: Survival horror and action in one big package
Watch the Resident Evil 6 announcement trailer below: