Although 2K Games is yet to officially unveil Kinect compatibility, the game's cover features the "Better With Kinect" logo, reports 360 Sync.
It is thought that Kinect features will extend to menu commands, teammate instructions and dynamic strategy calls.
Last week it was revealed that Jay-Z would be involved with NBA 2K13 as executive producer.
The rapper and media mogul will contribute to the "look and feel" of the title, hand-picking its soundtrack, designing the interactive menus and helping with the presentation.
The game releases for the Xbox 360, PS3, PlayStation Vita, Wii and PC on October 2 in North America. A European launch date is yet to be finalised.
It will also release for the Wii U. Listed for a "holiday" launch, it will likely be available within the first few months of the console's release.
Previous NBA 2K games have been well received, earning near-unanimous praise for their presentation, depth and polish.