The studio debuted the latest clip from the hack and slash title at gamescom, where it was confirmed that Dante's twin brother Virgil will return to the series.
Virgil, who appeared in Devil May Cry and Dante's Awakening, recruits his brother to fight alongside him in a group called the Order to vanquish a demon lord.
DmC: Devil May Cry will reboot the franchise, shifting the setting to a parallel universe with a younger, grittier Dante.
Dante will also partner with new character Kat, a skilled medium and psychic who guides Dante through her ability to see into Limbo, the demon realm.
The game is being developed by Ninja Theory, the team behind Enslaved: Odyssey To The West.
DmC: Devil May Cry is released for PlayStation 3 and Xbox 360 in January 2013.