Released as a follow-up to last week's video with Jake in the cabin, the latest trailer focuses on Chris, who goes face-to-face with one of the game's bosses.
The boss battle pays homage to the original Resident Evil, which also saw Chris go up against a huge snake.
Last week Capcom announced a dedicated free online Resident Evil service to store gameplay stats and help players find co-op matches.
Unveiled during Capcom's gamescom conference, ResidentEvil.net will showcase players' top scores for comparison with friends, introduce social features such as Twitter integration, and play host to official online competitions.
Announced earlier this year, Resident Evil 6 is set 15 years after the Raccoon City incident and takes place in the infected town of Tall Oaks, as well as China.
Capcom recently confirmed an unlockable Ada Wong campaign and unveiled a Left 4 Dead-inspired 'Agent Hunt' mode.
The game is the firm's largest ever production, with more than 600 staff involved in its development.
Resident Evil 6 will be available on Xbox 360 and PlayStation 3 on October 2. A PC release will follow, but has not yet been dated.
Screenshot gallery - Resident Evil 6 images: