Press outlets have begun receiving invitations to the event, which is scheduled for September 13 in New York City and will be hosted by Nintendo of America president Reggie Fils-Aime, reports Kotaku.
The event invitation does not specify that it will announce the Wii U price and release date, only saying that it will focus on "how the Wii U will change the future of gaming and entertainment".
A Nintendo spokesperson has told Digital Spy that there won't be an equivalent event in Europe.
"We are not planning a specific European event like NOA, however we are looking to put the new Wii U console in the hands of as many people across Europe as possible and we will be in contact with news of our UK communications plan in the near future."
Nintendo last held a similar event in New York and Amsterdam in 2011, during which it announced the price and release date for the Nintendo 3DS.
With the impending release for Nintendo's new console this holiday season, the firm will likely take the opportunity to outline its final release details for the Wii U.
Reports have indicated that the European release may be pushed back to later in the year.
The Wii U launch date has been the subject of much speculation since its unveiling at last year's E3 Gaming Expo.
Amazon Germany previously listed the console for a December 21 release, costing €399 - approximately £322/$506 - although it has since lowered the price.
The console has also been rumoured for a November release, through both Ubisoft at the E3 Gaming Expo and a leaked Black Ops 2 listing.
> Wii U: Digital Spy goes hands-on with Nintendo's new console - video
Watch the E3 Wii U Gamepad video below: