Styled after classic arcade games such as Smash TV, the game sends waves of enemies after the player in a single screen arena.
As an homage to the wild weapon variety found in the PC and console shooter, enemies will frequently drop new weapons with a wide range of stats and abilities.
The actual Borderlands 2 is coming next month, and boasts a 58-hour campaign that will take players to previously unseen regions of the planet Pandora.
A number of special editions will be available, including the Borderlands 2 Deluxe Vault Hunter's Collectors Edition and the Ultimate Loot Chest Limited Edition.
Borderlands 2 will be available for Xbox 360, PlayStation 3 and PC on September 18 in North America and on September 21 across Europe.
Play the 16-bit Borderlands 2 promo game in your browser here.
> Read our latest 'Borderlands 2' interview with Gearbox Software
> Digital Spy goes hands-on with 'Borderlands 2'
Watch the latest trailer for Borderlands 2 below: