The latest video shows how the Wii U gamepad's touchscreen will seamlessly integrate into the game to manage inventory, zoom with specific weapons and a range of other functions.
Announced at E3, ZombiU is a survival horror game where players must make their way through a zombie-infected London to reach the safe zone.
Dying will cause players to take control of a new character, and they must defeat the zombie of their previous life to recover equipment.
In addition to the single-player campaign, multiplayer will put one player in control of the zombie horde against a human opponent fighting for control of the map.
The game was confirmed today as a launch title for the Wii U, which will be available on November 18 in North America and November 30 in Europe.
Watch the ZombiU Buckingham Palace trailer below:
