Currently only confirmed for Japan, the new title roughly translates as Pokémon Mystery Dungeon: Magnagate and the Infinite Labyrinth. It was unveiled by Nintendo in Japan's CoroCoro magazine.
Playable Pokémon include Snivy, Oshawott, Tepig, Pikachu and Axew, while Unova region Pokémon are also said to feature.
The game will adopt a 3D art style and make use of the 3DS's augmented reality capabilities.
The Magnagate part of the title refers to the in-game portals preceding dungeons. Users will reportedly have the ability to scan as yet unannounced objects or codes to create new portals.
A 2013 Western release is unconfirmed, but likely, reports IGN.
Nintendo will soon release Pokémon Black 2 and White 2 for the original DS.
The games are the first direct sequels in the series. Nintendo traditionally denotes new additions to the franchise by colour, rather than numerically.
Pokémon Black 2 and White 2 will be set two years after their predecessors and see players return to the region of Unova.
The world has undergone numerous changes since the previous games, and will play host to new characters.
The launch of the sequels will be accompanied by the release of the Nintendo 3DS Pokémon Dream Radar app, which utilises the system's camera, motion control and augmented reality technology, enabling players to catch Pokémon by scanning the room and shooting a beam.
The app will contain a combination of rare and standard Pokémon, all of which will be transferable to Pokémon Black 2 and White 2 when captured.
Watch a trailer for Pokémon Black 2 and White 2 below: