The trailer outlines how Sam Fisher is granted the fifth freedom, putting him outside the law to complete his missions.
Splinter Cell: Blacklist was unveiled by Ubisoft during Microsoft's E3 press conference.
The game will feature Kinect integration on Xbox 360, allowing players to distract enemies and call for support using voice commands.
The plot will follow the events of Splinter Cell Conviction, as Sam Fischer must hunt down a mysterious terrorist organisation known as the Blacklist.
Splinter Cell: Blacklist is currently confirmed for the Xbox 360, PS3 and PC next year. A Wii U version has also been rumoured, but remains unconfirmed by Ubisoft.
Watch a gameplay demo for Splinter Cell: Blacklist below: