Teased on Facebook earlier this week, Splinter Cell: Echoes will cover the events between Conviction and Blacklist.
Written by Nathan Edmondson and illustrated by Marc Laming, whose respective credits include Ultimate Comics: Iron Man and Planet of the Apes, the graphic novel will be released in 2013.
Describing protagonist Sam Fisher as a "complicated character with a broken and dark past", Edmondson told IGN that Fisher "lends himself obviously and easily to storytelling beyond the game".
Edmondson went on to explain the role Ubisoft played in helping to create the comic.
"Nothing has been dictated to us. The Splinter Cell Toronto team and the Tom Clancy folks have been partners with us all the way, giving input, encouraging ideas, helping us to better understand the Splinter Cell world, but they have never harnessed our creativity."
Splinter Cell: Blacklist was unveiled by Ubisoft during Microsoft's E3 press conference.
The game will feature Kinect integration on Xbox 360, allowing players to distract enemies and call for support using voice commands.
The plot will follow the events of Splinter Cell Conviction, as Sam Fisher must hunt down a mysterious terrorist organisation known as the Blacklist.
Splinter Cell: Blacklist is currently confirmed for the Xbox 360, PS3 and PC next year. A Wii U version has also been rumoured, but remains unconfirmed by Ubisoft.
> 'Splinter Cell: Blacklist' cinematic lead talks current console limits
Watch a trailer for Splinter Cell: Blacklist below: