Players will be able to challenge the real Pokemon World Championship finalists in-game during set events throughout October and November.
Starting on October 22, players who connect their game online through a Wi-Fi connection will be able to go to Driftveil City and enter the '2012 Junior Division Challenge' to compete against the junior division's world champion and the top three runners up from the junior division.
The '2012 Senior Division Challenge' will unlock through a Wi-Fi connection from November 5, and finally the '2012 Masters Division Challenge' will be available from November 19.
Pokemon Black Version 2 and Pokemon White Version 2 released earlier this month on Nintendo DS, marking the first direct sequels in the long-running series.
> Digital Spy's review of Pokemon White Version 2: Evolution, not revolution
Watch the trailer for Pokemon Black 2 and White 2 below: